Doctor's Assistant: Anything else in your medical history you think the doctor should know?Metaplasia is defined as a change of one cell type to another cell type. Location: Needham,MA. during your monthly. 12. read more. In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed,. Endometrial biopsy was performed 3 to 4 weeks after completion of therapy to assess response. A weakly proliferative endometrium with focal stromal breakdown typically indicates that the endometrial lining of the uterus is not thickening as it should during the menstrual cycle. Endometrium, EMC Final Diagnosis A. What does a weakly proliferative endometrium mean? It is probable that the presence of a weak proliferative pattern in a postmenopausal atrophic endometrium is a response of the uterine mucosa to continuous low level oestrogenic stimulation. The lining of the uterus (endometrium) becomes unusually thick because of having too many cells (hyperplasia). The belief that stromal cell proliferations in the endometrium are by definition neoplastic was first challenged by Stewart et al. that is what weakly proliferative endometrium means. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. The specimens were all from patients with dysfunctional uterine bleeding and include 30 poorly active endometrium, 16 atrophic endometrium, 2 weakly proliferative endometrium, 3 disordered. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. stroma. Metaplasia is defined as a change of one cell type to another cell type. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. Plasma cells were rare in inactive endometrium and noted in only 18% of unremarkable proliferative endometrium, all grade 1. This pictorial review takes you through the hysteroscopic view of normal-looking. [10]: (1) constant appearance of basalis throughout the menstrual cycle, (2) glands of the basalis appear weakly proliferative, (3) basalis cells lack secretory features and the stroma is spindled. Markedly atypical nuclei identical to those of invasive serous carcinomas, lining the surfaces and glands of an atrophic endometrium. 1,758 satisfied customers. Microscopic (histologic) description. While secretory changes in endometrial glands can be observed occasionally at birth, decidual or menstrual changes are rare ( 25 ). This code is applicable to female patients only. 5 years; P<. Recognition as an Endometrial Stromal Neoplasm (Biopsy/Curettage Specimen) The first clue that a biopsy/curettage specimen harbors an endometrial stromal neoplasm is the finding of multiple. -- balls of condensed endometrial stroma. X. 0001) and had a higher body mass index (33. The proliferative phase is the variable part of the cycle. MD. Definition focal overgrowth of localized benign endometrial tissue. It is also simply known as endometrial polyp which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. read more. Stroma is the connective tissue just below the surface of an organ. Endometrial Changes During the Menopause An endometrium that atrophies and loses it functional layer, with endometrial stroma that becomes fibrous andThe primary symptom of endometrial hyperplasia is abnormal menstrual bleeding. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). It’s not cancer, but in certain women, it raises the risk of developing endometrial cancer, a type of uterine cancer. Treatment for endometrial cancer usually involves an operation to remove the uterus, called a hysterectomy. Some fragments may represent. EH with atypia is neoplastic and may progress or coexist with endometrial carcinoma. More African American women had a. Ultrasound Results mild endometrial thickening 7-8 mm. Uterine polyp and endometrial polyp redirect here. A menstrual cycle for one woman may last for a few days but for another woman may last a. Serous carcinoma is the prototypic endometrial carcinoma that is not related to estrogenic stimulation and typically occurs in the setting of endometrial atrophy. They described functional endometrium as being “weakly proliferative” or “weakly. what does that mean?1. 2 Proliferative Endometrium4,572 satisfied customers. Endometrial changes of oral contraception, oral contraceptive effect, OCP endometrium, and endometrium with hormonal changes redirect here. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, some-what tortuous, with tall columnar pseudostratified(tend to diagnose disordered proliferative endometrium in perimenopausal years) •occasional dilated glands with proliferative activity, stromal breakdown, metaplasias (especially ciliated). The pathologist must be aware of the spectrum of endometrial metaplasias encountered and the clinical setting in which they. 0; range, 1. Inactive endometrium is normal in post menopausal women. Abstract Background: Proliferative endometrium has been reported in 15% of endometrial biopsies of women aged 50 years and older. 2 vs 64. 5 years; P<. Recognition as an Endometrial Stromal Neoplasm (Biopsy/Curettage Specimen) The first clue that a biopsy/curettage specimen harbors an endometrial stromal neoplasm is the finding of multiple. 9 and 12. Disordered proliferative endometrium with glandular and. Glands/cells identical to proliferative endometrium Abundant stroma Gland:Stroma ratio often 1:1, if becomes >2:1, then consider hyperplasia (see endometrial tumor notes) Often coinciding breakdown Endometrial glands and stroma outside of their usual endometrial cavity location→cause dysmenorrhea and/or menorrhagia Adenomyosis Atrophic endometrium is a normal finding in prepubertal, postmenopausal, and some perimenopausal women. Ultrasound(pelvic and trans vaginal) that homogeneous endometrium is seen measuring 5 - 6 mm. Share. Proliferative Dilated proliferative type glands, with pseudostratification Focal breakdown common Due to unopposed estrogen Irregularly Developed Secretory type glands co-exist with proliferative glands. 2 vs 64. At this. Blood. 5 ±17. The endometrium becomes thicker leading up to ovulation to provide a suitable environment for a fertilized egg to grow inside the uterus. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. 2; median, 2. This is essentially a normal report for your age. 4 × 10 −3 mm 2 /s,. During menopause, the ovaries produce fewer hormones, leading to a cessation of the menstrual cycle. Endometrial hyperplasia (EH) is a pre-cancerous, non-physiological, non-invasive proliferation of the endometrium that results in increased volume of endometrial tissue with alterations of glandular architecture (shape and size) and endometrial gland to stroma ratio of greater than 1:1 [5,6]. It is also known as atrophy of the endometrium and endometrial atrophy . Read More. Proliferative activity is relatively common in postmenopausal women ~25%. "FRAGMENTS OF WEAKLY PROLIFERATIVE ENDOMETRIUMWITH GLANDULAR AND STROMALBREAKDOWN"? Can somebody explain this to me in English please? Answer. Proliferate definition: . No malignancy was recognized. 3,291 satisfied customers. Abstract. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Microscopic findings. Eosinophilic cell change was more frequently seen in endometrial hyperplasia and carcinoma than in benign nonhyperplastic endometrium. Normal: After menstruation is over the lining of the endometrium begins to proliferate and grow. Figure 1. Endometrial receptivity describes the intricate process undertaken by the uterine lining to prepare for the implantation of an embryo. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, somewhat tortuous, with tall columnar pseudostratified epithelium, oval. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. "what does it mean? inactive endometrium with focal tubal metaplasia? benign endometrial polyp. Proliferative endometrium describes the 'stage' of the endometrium when it was biopsied. I am postmenopausal with uterine bleeding. Furthermore, 962 women met the inclusion criteria. 7. Endometrial polyps are common and usually benign. Early diagnosis and treatment of EH (with or without atypia) can prevent progression to. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. We performed p16 immunostaining on 35 normal endometrial specimens and 32 EPs, six of which were associated with tamoxifen therapy. 04, 95% CI 2. Created for people with ongoing healthcare needs but benefits everyone. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. thank you endometrium, biopsy: -glandular and stromal breakdown, consistent with bleeding changes -negative for atypia or malignancy?. Wendy Askew answered. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. Read More. resembling proliferative phase endometrium. PMID: 11584479. Exogenous hormones taken for various reasons may have an effect on the morphology of endometrium, endometrial stroma and myometrial lesions, such as leiomyomas. This is the American ICD-10-CM version of N85. 2; median, 2. Gurmukh Singh answered. In addition, the term “carcinoma in situ” was proposed to describe small lesions, with or. There is, however, variation within the endometrial thickness depending on the vertical position of the tissue in relation to the surface epithelium and the endometrial–myometrial junction (Figure 14. Cancer can affect the uterus, the hollow, pear-shaped organ where a baby grows. What does weakly proliferative endometrium mean. EH, especially EH with atypia, is of clinical significance because it may progress to. DDx. Hysteroscopy can identify malignant or benign pathology with approximately 20% false-positive results. How is proliferative endometrium treated? Endometrial hyperplasia treatment The most. May be day 5-13 - if the menstruation is not included. ( I have had 5 endometrium biopsies over past 4 years and one D&C 6 years ago) • 01-2021 Endo Biopsy Diagnosis: Pre-hyperplasia, Disordered proliferative endometrium without atypia. On pap tests this is associated with the classic double contoured balls of endometrial epithelium and stroma. During the last on-therapy visit, 48 subjects (52%) had an endometrium categorized as other, which included primarily an inactive or benign endometrium (n=42). This raises the concern for hyperplasia vs. 2; median, 2. The immunohistochemical staining pattern for CD138 with appropriate controls supports the above diagnosis. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the. 0 x 0. The diagnosis is usually made after a small sample of tissue is removed from the endometrium during a procedure called an endometrial biopsy or uterine curetting. Doctor's Assistant: When was your last pap smear? Have you ever had an irregular pap? My pap was good clinical history is abnormal uterine bleeding. The level of staining intensities in the weakly proliferative endometrial epithelial cells was relatively low, and the staining signal was weak (1+). SEE COMMENT. Methods. "Sections show background weakly proliferative endometrium with areas of metaplastic glands (eosinophilic, mucinous and tubal) which exhibit crowding and complex architecture, including cribriforming. Normal cyclical endometrium showed patchy glandular staining and there was also focal stromal p16 expression in the functional layer of most proliferative and secretory endometria. The 2024 edition of ICD-10-CM N85. Cytoplasmic vacuoles become supranuclear and secretions are seen within glandular lumina (Fig. This is done to evaluate infertility or dysmenorrhea. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Dr R. Proliferative endometrium isn’t a symptom or condition. Looking for help on a biospy report : weakly proliferative endometrium with progestin effect description is Fixative:Formalin NO. Proliferative-type epithelial glands, somewhat tortuous, with tall columnar pseudostratified epithelium, oval nuclei, and very infrequent mitoses (c) A dense fibrotic endometrial stroma devoid of mitoses. 0001). 0001) and had a higher body mass index (33. No apparent endometrial hyperplasia was seen. Contrary to endometrial hyperplasia,. I'm sure your physician is monitoring your endometrial lining via biopsy or D&C to make sure that you aren't at increased risk of endometrial hyperplasia or pre-cancer of the endometrium. 11. Hormonal imbalances: Hormonal imbalances, such as decreased levels of estrogen and progesterone, can contribute to the endometrium. It is a normal finding in women of reproductive age. read moreSpecimens A. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. Main. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. These sound like the results from an endometrial biopsy - basically, when your doctor takes a clipping or scraping from inside the uterus and sends it off to a pathologist to be examined. Definition / general. 00 - other international versions of ICD-10 N85. The endometrium represents the inner glandular epithelial lining of the uterus and provides a nourishing environment for possible implantation of the blastocyst. The risk. 8% of all surgical specimens of women with PE. It may be associated with abnormal menstrual bleeding or infertility. Endometrial cancer is a type of cancer that begins as a growth of cells in the uterus. read more. 0001). This definition comprises various types of hormonally induced metaplastic changes in the endometrium observed both in benign and premalignant or malignant conditions [9,10,11]. Endometrial polyps. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Read More. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. Chronic plasmacytic endometritis (CPE) is an infectious or reactive process with multiple etiologies. the mean age, weight, FSH and oestradiol. It says "weakly proliferative with stromal breakdown, negative for hyperplasia or carcinoma. Prognosis. More African American women had a proliferative. These layers become more pronounced. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. -- abundant neutrophils and blood. An “insufficient” EMB result should always be viewed cautiously, especially in the setting of persistent postmenopausal bleeding. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Endometrial Polyp - Fragments of weakly proliferative/ inactive endometrium. 6 kg/m 2; P<. The Proliferative Phase. Of the 142 specimens, 59 (41. This may explain the development of endometrial adenocarcinoma in. 1 To fulfil this latter role, the endometrium is unique in that it undergoes cyclical epithelial and stromal morphogenesis during the reproductive years. To understand it fully, estrogen and progesterone are the 2 hormones that makes this proliferation in order. Early proliferative (day 4-7 ) Straight short glands, thin epithelium. The use of both estrogen and progesterone elicits a wide range of histologic patterns, seen in various combinations: proliferative and secretory changes, often mixed in the same tissue sample; glandular. There is a clinically insignificant 16% pathologic underdiagnosis rate. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. Read More. Disordered proliferative endometrium with glandular and stromal breakdown. proliferative endometrial glands (pseudostratified nuclei + mitoses) with focally abnormal glands (glands >2x normal size; irregular shape -- typically with inflection points; >4 glands involved (dilated)), +/-stromal condensation, gland-to-stromal ratio normal, not within an endometrial polyp. People who have atypical endometrial hyperplasia have a higher risk of developing uterine cancer. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown. Metaplasia is defined as a change of one cell type to another cell type. The significance of the findings is that the metaplasia may present an. Proliferative endometrium(15%) and secretory endometrium (5%) were identified in the postmenopausal women which is a comparable finding to other studies that reported a proliferative endometrium. "Exodus" pattern is a term used to describe exfoliation of endometrial cells during the proliferative phase. 5% Menstrual Endometrium 52 5. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM. The uterus is lined with a special tissue called the endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and ‘atypical’ forms of EH are regarded as premalignant lesions. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. Instead, DPE is characterized by irregularly shaped, cystically dilated glands producing a disordered arrangement. When cancer grows in this lining, it is called. Open in a separate window. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. Adenomyosis is distinct from endometriosis, which is the presence of endometrial. This definition comprises various types of hormonally induced metaplastic changes in the endometrium observed both in benign and premalignant or malignant conditions [9,10,11]. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. 00 is a billable diagnosis code used to specify a medical diagnosis of endometrial hyperplasia, unspecified. Physician. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. your doctor should check your estrogen and LH and FSH hormone levels to see if they are normal. Hysteroscopy can identify malignant or benign pathology with approximately 20% false-positive results. Uterine corpus cancer is the most prevalent gynecologic malignancy in American women with over 60,000 new cases expected during the next year and accounting for nearly 11,000 deaths. No evidence of endometrium or malignancy. 5 ±17. Dr. This article discusses briefly. Dr. Harold Fields answered. Your GP probably hadn't had time or knowledge that the report was ready to read. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. Figure 1. 5%. Ed Friedlander and 4 doctors agree. Created for people with ongoing healthcare needs but. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. Unremarkable squamous epithelium is also normal and mucus is a normal finding. Definition and Classification. The asymptomatic disease free postmenopausal endometria derived from the prolapsed uteruses were atrophic and inactive in 42 of the 84 women, atrophic and weakly proliferative in 22, and of mixed form in 20 women. Most endometrial carcinomas maintain endometrioid differentiation; these also can contain areas of mucinous or squamous differentiation. Hence, it is also known as Metaplastic Changes in Endometrial Glands. Symptoms. Disordered proliferative endometrium accounted for 5. Created for people with ongoing healthcare needs but benefits everyone. g. It may be associated with abnormal menstrual bleeding or infertility. Oral contraceptives (OCs) containing a low-dose, low-potency progesterone and low-dose estrogen stop proliferation of the glands during the 1st few cycles and the glands are. In the present pictorial review, we briefly discuss the various morphologic. Created for people with ongoing healthcare needs but benefits everyone. Europe PMC is an archive of life sciences journal literature. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, somewhat tortuous, with tall. K. 10. In the endometrial carcinoma, the staining signal was. Benign endometrial polyp, abbreviated BEP, is a common diagnosis in endometrial specimens. 0 x 3. What do the results of my endometrial biopsy mean? Here are some words and phrases you might see on your biopsy results: Proliferative endometrium; Atrophic endometrium ; Hyperplasia; Carcinoma; If you see either of the first two phrases, your results are normal. Endometriosis can affect women of any age, including teenagers. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. SEE COMMENT. What is the meaning of proliferative endometrium? The proliferative endometrium stage is also called the follicular phase. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. The specimen is received. 2 percent) Hyperplasia without atypia (2 percent) Hyperplasia with atypia (0. Limitation of this study is the small number of cases studied. Keywords: endometrium, atrophic, inactive, weakly proliferative, endometrial adenocarcinoma. Endocervical/tissue: A "pap smear" may contain some tissue from the canal leading to the womb (endocervical canal) which grows out over the surface of the cervix and is se. I. General Surgeon. 8% of hysteroscopies and in 56. Fragments of benign leiomyoma. Definition / general. Blood. Can be pedunculated or sessile, single or multiple, and up to many centimeters in size. The endometrial. (2) Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. N85. The detection rate for endometrial cancer is approximately 99. "pathology report states: postmenapausal weakly-proliferative endometrium with focal glandular crowding. Even if the 50% (1:1) cutoff is the most practical from a diagnostic and clinical perspective, what. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. Dr. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. . Proliferative endometrium is part of the female reproductive process. May be day 5-13 - if the menstruation is not included. « lining in uterus thickened | Cells from uterus that show up in a pap ». Postmenopausal bleeding. g. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. Endometrial hyperplasia is a disordered proliferation of endometrial glands. 4. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. 9 vs 30. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. Harold Fields answered. does scant superficial strips of inactive endometrium seperate fragments of unremarkable squamous epithelium & mucus mean on an endometrial biops? 1 doctor answer • 2 doctors. 0–3. Created for people with ongoing healthcare needs but benefits everyone. 02 may differ. Results: All postmenopausal endometria were atrophic, but only 42 were inactive; of the remaining samples, 22 were weakly proliferative and 20 were mixed active and inactive. Women with a proliferative endometrium were younger (61. After menstruation, proliferative changes occur during a period of tissue regeneration. What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without hyperplasia or malignancy. Adenofibroma. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. During. focal mucinous metaplasia. The 2024 edition of ICD-10-CM N85. I had a biopsy with a d and c 15 weeks ago that was returned benign, negative for hyperplasia and carcinoma. 1,762. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. The endometrium is the mucous membrane that is found lining the inside of the uterus, and the term ‘Disordered Proliferative Endometrium’ is used to describe a hyperplastic appearance of the. The phenomenon of endometrial metaplasia was first described comprehensively by Hendrickson and Kempson in 1980. It's a long-term condition that can have a significant impact on your life, but there are treatments that can help. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. No evidence of endometrium or malignancy. 0001). 09–7. . I was diagnosed with disordered proliferative endometrium with glandular and stromal breakdown, benign polyps simple hyperplasia w/o atypia, a fibroid size of grapefruit pressing on bladder. 3,245 satisfied customers. It is further classified. 1. An endometrial biopsy is generally performed in cases of 'dysfunctional uterine bleeding' - meaning, bleeding that is heavy, irregular, or otherwise. 81, p < 0. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. X. Weakly proliferative endometrium shows a pattern intermediate between normal proliferative and atrophic. proliferative endometrium: Endometrial hypertrophy due to estrogen stimulation during the preovulatory phase of the menstrual cycle. Conclusion One in six postmenopausal women who underwent endometrial sampling had proliferative endometrium. Endometrial Stromal Nodule (ESN) and Low-Grade Endometrial Stromal Sarcoma (LG-ESS) ESN is a benign, whereas LG-ESS is a malignant neoplasm of the uterus (affecting the body of the uterus more than the cervix) and extra-uterine sites [8,9]. It can be acute (starts suddenly and is short-term) or chronic (lasts a long time or occurs repeatedly). The lesion is reportedly often associated with pelvic inflammatory disease and intermenstrual bleeding. Interestingly, presence of polyp tissue was associated with endometrial cancer outcome in both the unadjusted (univariate) and adjusted (multivariable) models (OR 4. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. Localized within the uterine wall, extends into the uterine cavity. 02 - other international versions of ICD-10 N85. Normal proliferative endometrium contains glands that are regularly spaced and that lie within stroma at a gland: stroma ratio of 1 to 1. Dr. Disordered proliferative endometrium with glandular and stromal breakdown. Atrophic endometrium, also inactive endometrium, is the normal finding in postmenopausal women. "My gynecologist did the biopsy to rule out uterine cancer (which neither of us thought I had), as we try to determine the cause of my dysfunctional uterine bleeding. Introduction. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium ), cell changes that are benign (ciliated metaplasia) & no precancerous or cancerous cells. What does disordered proliferative endometrium mean? Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. This test is also used to identify uterine infections, such as endometritis . Contexts. Conclusions: At least half of the disease free postmenopausal atrophic endometria show a weak proliferative pattern, either diffuse or focal, probably as a response to continuous. when they faced with a series of two endometrial biopsies and a subsequent hysterectomy specimen of a young woman with menorrhagia. Dating of endometrium: Proliferative phase. By definition, adenocarcinoma of the endometrium is an invasive disease, invading either the endometrial stroma or the underlying myometrium of extrauterine tissues.